中间体
发布日期：2019-11-07 浏览次数：7559
| Intermediates List | |||
| Usage | Product | CAS No. | Documentation |
| Lamivudine | L-Menthyl glyoxylate monohydrate (L-MGH) | 111969-64-3 | Technical Package |
| (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (HME) | 147126-62-3 | Technical Package | |
| (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (CME) | 147027-10-9 | DMF/US FDA | |
| (2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]- 2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate) | 173522-96-8 | Technical Package | |
| Ritonavir | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT) | 144163-97-3 | Technical Package |
|
N-[2-Isopropylthiazol-4-ylmethyl
(methyl)-carbamoyl]-L-valine (MTV-III) |
154212-61-0 | Technical Package | |
| (2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2 succinate salt (BDH succinate salt) | 183388-64-9 | Technical Package | |
| (2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH PURE) | 144163-85-9 | Technical Package | |
| Cobicistat | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT) | 144163-97-3 | Technical Package |
| 2-Isopropyl-4(((N- Methyl)amino) methyl)thiazole Dihydrochloride (MTV 2HCl) | 1185167-55-8 | Technical Package | |
| Entecavir | (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)-diphenylmethyl] amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl) cyclopentanol (Ent-V) | 142217-78-5 | Technical Package |
| 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (Ent-VII) | 142217-80-9 | Technical Package | |
|
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-
2-methylenecyclopentyl]-6H- purin-6-one (Ent-VIII) |
142217-81-0 | Technical Package | |
| Emtricitabine | (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl-1-yl)-[1,3] oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (FCME) | 764659-72-5 | Technical Package |
|
Tenofovir Disoproxil Fumarate |
(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) |
147127-20-6 | Technical Package |
|
Bedaquiline Fumarate |
3-Benzyl-6-bromo-2-methoxyquinoline (BBMQ) |
654655-69-3 |
-- |
| 3-Dimethylamino-1-(naphthalen-1-yl) propan-1-one hydrochloride (DMNP) |
5409-58-5 |
-- | |
| Lopinavir | N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide 5-oxopyrrolidine-2-carboxylic acid (THP) | 192726-06-0 | -- |
|
Tenofovir Alafenamide Fumarate |
(S)-Isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)-phosphoryl)amino)propanoate (TA) | 379270-37-8 | -- |
| 9-[(R)-2-(phenylphosphonomethoxy) propyl]adenine (PPMPA) | 379270-35-6 | -- | |
| Dolutegravir | (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid | 1335210-34-8 | -- |
| (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1335210-35-9 | -- | |
|
Selegiline Hydrochloride |
N,N-dimethyl-N'-(1-phenylpropan-2-yl)-Sulfamide | 1875882-12-4 | -- |
| (2R)-1-phenyl-N-prop-2-ynylpropan-2-amine hydrochloride | 115586-38-4 | -- | |
| R-(-)-N-Demethyl Deprenyl | 56862-28-3 | -- | |
| R & D List | |||
| Abacavir Sulfate | (1R,4S)-4-amino-2-Cyclopentene-1-methanol hydrochloride | 287717-44-6 | -- |
| 2-amino-4,6-dichloro-5-formamidopyrimidine | 171887-03-9 | -- | |
| Obeticholic Acid | 3alpha-Hydroxy-7-oxo-5beta-cholic acid | 4651-67-6 | -- |
| Methyl 7-keto-3alpha-hydroxy-5beta-cholanoate | 10538-59-7 | -- | |
| (R)-methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | 336099-76-4 | -- | |
| (R)-methyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | 1516887-31-2 | ||
| (R)-methyl 4-((3R,6S)-6-ethyl-hexadecahydro-3-hydroxy-10,13-dimethyl-7-oxo-1H-cyclopental[a]phenanthren-17-yl)pentanoate | 1654780-32-1 | ||
| (3alpha,5beta,6alpha)-6-Ethyl-3-hydroxy-7-oxocholan-24-oic acid | 915038-26-5 | -- | |
| Rilpivirine | 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile | 189956-45-4 | -- |
| 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile | 244768-32-9 | ||
| 4-Iodo-2,6-dimethylaniline | 4102-53-8 | -- | |
| 3-(4-amino-3,5-dimethylphenyl)prop-2-enamide | 500292-92-2 | ||
| (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride | 661489-23-2 | -- | |
| * Patent-protected area, not to be sold. | |||
| www.fhjkyh.com / info@bcpharm.com / WeChat: bcpharm | |||
| Intermediates List | |||
| Usage | Product | CAS No. | Documentation |
| Lamivudine | L-Menthyl glyoxylate monohydrate (L-MGH) | 111969-64-3 | Technical Package |
| (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (HME) | 147126-62-3 | Technical Package | |
| (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (CME) | 147027-10-9 | DMF/US FDA | |
| (2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]- 2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate) | 173522-96-8 | Technical Package | |
| Ritonavir | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT) | 144163-97-3 | Technical Package |
|
N-[2-Isopropylthiazol-4-ylmethyl
(methyl)-carbamoyl]-L-valine (MTV-III) |
154212-61-0 | Technical Package | |
| (2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2 succinate salt (BDH succinate salt) | 183388-64-9 | Technical Package | |
| (2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH PURE) | 144163-85-9 | Technical Package | |
| Cobicistat | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT) | 144163-97-3 | Technical Package |
| 2-Isopropyl-4(((N- Methyl)amino) methyl)thiazole Dihydrochloride (MTV 2HCl) | 1185167-55-8 | Technical Package | |
| Entecavir | (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)-diphenylmethyl] amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl) cyclopentanol (Ent-V) | 142217-78-5 | Technical Package |
| 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (Ent-VII) | 142217-80-9 | Technical Package | |
|
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-
2-methylenecyclopentyl]-6H- purin-6-one (Ent-VIII) |
142217-81-0 | Technical Package | |
| Emtricitabine | (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl-1-yl)-[1,3] oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (FCME) | 764659-72-5 | Technical Package |
|
Tenofovir Disoproxil Fumarate |
(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) |
147127-20-6 | Technical Package |
|
Bedaquiline Fumarate |
3-Benzyl-6-bromo-2-methoxyquinoline (BBMQ) |
654655-69-3 |
-- |
| 3-Dimethylamino-1-(naphthalen-1-yl) propan-1-one hydrochloride (DMNP) |
5409-58-5 |
-- | |
| Lopinavir | N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide 5-oxopyrrolidine-2-carboxylic acid (THP) | 192726-06-0 | -- |
|
Tenofovir Alafenamide Fumarate |
(S)-Isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)-phosphoryl)amino)propanoate (TA) | 379270-37-8 | -- |
| 9-[(R)-2-(phenylphosphonomethoxy) propyl]adenine (PPMPA) | 379270-35-6 | -- | |
| Dolutegravir | (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid | 1335210-34-8 | -- |
| (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1335210-35-9 | -- | |
|
Selegiline Hydrochloride |
N,N-dimethyl-N'-(1-phenylpropan-2-yl)-Sulfamide | 1875882-12-4 | -- |
| (2R)-1-phenyl-N-prop-2-ynylpropan-2-amine hydrochloride | 115586-38-4 | -- | |
| R-(-)-N-Demethyl Deprenyl | 56862-28-3 | -- | |
| R & D List | |||
| Abacavir Sulfate | (1R,4S)-4-amino-2-Cyclopentene-1-methanol hydrochloride | 287717-44-6 | -- |
| 2-amino-4,6-dichloro-5-formamidopyrimidine | 171887-03-9 | -- | |
| Obeticholic Acid | 3alpha-Hydroxy-7-oxo-5beta-cholic acid | 4651-67-6 | -- |
| Methyl 7-keto-3alpha-hydroxy-5beta-cholanoate | 10538-59-7 | -- | |
| (R)-methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | 336099-76-4 | -- | |
| (R)-methyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | 1516887-31-2 | ||
| (R)-methyl 4-((3R,6S)-6-ethyl-hexadecahydro-3-hydroxy-10,13-dimethyl-7-oxo-1H-cyclopental[a]phenanthren-17-yl)pentanoate | 1654780-32-1 | ||
| (3alpha,5beta,6alpha)-6-Ethyl-3-hydroxy-7-oxocholan-24-oic acid | 915038-26-5 | -- | |
| Rilpivirine | 4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile | 189956-45-4 | -- |
| 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile | 244768-32-9 | ||
| 4-Iodo-2,6-dimethylaniline | 4102-53-8 | -- | |
| 3-(4-amino-3,5-dimethylphenyl)prop-2-enamide | 500292-92-2 | ||
| (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride | 661489-23-2 | -- | |
| * Patent-protected area, not to be sold. | |||
| www.fhjkyh.com / info@bcpharm.com / WeChat: bcpharm | |||
